Nonlinear Fitness Landscape of a Molecular Pathway Supplementary Material
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Nonlinear Fitness Landscape of a Molecular Pathway
Genes are regulated because their expression involves a fitness cost to the organism. The production of proteins by transcription and translation is a well-known cost factor, but the enzymatic activity of the proteins produced can also reduce fitness, depending on the internal state and the environment of the cell. Here, we map the fitness costs of a key metabolic network, the lactose utilizati...
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تاریخ انتشار 2011